Clinical characteristics of patients with ketosis-onset diabetes

VernacularTitle:酮症起病糖尿病患者105例病因分型的临床研究
Author: Bo LIU ; Ye JI ; Yingdi SHEN ; Hairong TIAN ; Zhiyun LI
Publication Type:Journal Article
Keywords: Diabetic ketoacidosis; Insulin-secreting cells metabolism
From: Chinese Journal of General Practitioners 2012;11(2):137-139
CountryChina
Language:Chinese
Abstract: A total of 105 patients with ketosis-onset diabetes were divided into four groups (A+B-,A + B +,A - B -,A - B +) based on the results of islet-associated autoantibodies (A +,A - ) and β-cell function (B +,B - ).Nearly 94％ patients in the A -B + group and 1/10 patients in the A - B - group were non-insulin dependent.While in the A + B - and A + B + groups,the detection rates of subsequent non-insulin dependency were 20％ and 58％,respectively.Among the four groups,patients in the A - B + groups had a lower level of IL-6 and a higher level of TNF-α. Patients in the A + B - and A + B + groups had a higher level of IL-18.Our study indicates that patients with ketosis-onset diabetes may present different clinical characteristics. Evaluate the islet-associated autoantibodies and pancreatic β-cell function may be helpful to the clinical diagnostic and therapeutic strategies in diabetes.