Correlation between serum vascular endothelial cells cadherin level and atherosclerosis in diabetic patients
10.3760/cma.j.issn.1000-6699.2011.08.007
- VernacularTitle:糖尿病患者血清可溶性血管内皮细胞钙黏蛋白水平与动脉粥样硬化关系的临床研究
- Author:
Ying XIE
;
Soujiang YOU
;
Ruhong YAN
;
Yongjun CAO
;
Yanlin ZHANG
;
Jixiang DONG
;
Chunfeng LIU
- Publication Type:Journal Article
- Keywords:
Vascular endothelial cells cadherin;
Glycation end-products,advanced;
Diabetes mellitus;
Atherosclerosis
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(8):641-643
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship among serum vascular endothelial cells(VE) -cadherin, advanced glycation end-products( AGE), and atherosclerotic lesion. 20 healthy subjects and 60 patients with diabetes mellitus,including 30 patients with carotid atherosclerosis (CI), were enrolled.Soluble VE-cadherin and AGE were determined using the enzyme-linked immunosorbent method (ELISA). The relationships among the concentration of soluble VE-cadherin, AGE, and the course of the disease, blood glucose, and blood lipid levels were analyzed with multivariant stepwise regression analysis. The levels of serum VE-cadherin and AGE in the patients with diabetes and CI were higher than those in control group( P＜0. 05 ). There was a significant difference in VE-cadherin between the diabetes group and the CI group( P＜0. 05 ). Serum VE-cadherin levels were positively correlated with serum AGE levels(r = 0. 69, P＜0. 01 ). AGE levels were positively correlated with the diabetes duration ( r = 0. 31, P =0. 02 ). The levels of serum VE-cadherin in diabetic patients are positively correlated with their serum AGE levels. The VE-cadherin seems to play an important role in the development of atherosclerosis caused by AGE.
