Indoleamine-pyrrole 2,3-dioxygenase might be a prognostic biomarker for patients with renal cell carcinoma

VernacularTitle:吲哚胺吡咯2,3-双加氧酶与肾细胞癌预后的预测
Author: Fang YUAN ; Yinghong LIU ; Xiao FU ; Junxiang CHEN
Publication Type:Journal Article
Keywords: indoleamine-pyrrole 2,3-dioxygenase; renal cell carcinoma; endothelial cell; prognostic biomarker
From: Journal of Central South University(Medical Sciences) 2012;37(7):649-655
CountryChina
Language:Chinese
Abstract: Objective:To explore the role of indoleamine-pyrrole 2,3-dioxygenase (IDO),an immunomodulatory enzyme,in renal cell carcinoma (RCC).Methods:A total of 40 patients diagnosed as RCC in the Second Xiangya Hospital were included in this study.All patients received nephrectomy.The histopathological features of samples were assessed semi-quantitatively.IDO mRNA level in RCC and non-RCC renal tissues was determined by real-time quantitative PCR (RT-qPCR).And the expression of IDO protein in endothelial cells was examined by immunohistochemistry; a Kaplan-Meier survival curves was calculated on the basis of IDO mRNA level.Results:Level of IDO mRNA in RCC samples was significantly higher than that in tumor-free samples with P＜0.001.Patients with high IDO expression had an significantly longer survival time than those with low IDO expression (P=0.01).There was a statistically significant inverse correlation between IDO and proliferation marker Ki67.Patients with high IDO level were of low Ki67 level,and vice versa (P＜0.01).Conclusion:IDO might be a prognostic biomarker for patients with RCC.