Detection and clinical significance of microvascular density labeled by CD105 in hepatocellular carcinoma and adjacent non-tumorous tissues
10.3760/cma.j.issn.1007-8118.2011.12.008
- VernacularTitle:原发性肝细胞癌以及近癌旁组织微血管密度CD105表达及其临床意义
- Author:
Jianping ZHANG
;
Sanyuan HU
;
Jialian NI
;
Hongbiao JING
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Adjacent nontumorous tissues;
Microvessle density
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(12):978-981
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the specificity of CD105 labeled microvessel density (MVD)and its clinical significance.Methods Formalin fixed,paraffin wax embedded specimens from 63 patients with hepatocellular carcinoma (HCC) were stained with anti-CD105 monoclonal antibody.A correlation was analyzed between the expression and distribution of MVD-CD105 in HCC/adjacent non-tumorous tissues and clinicopathological features.Results CD105 immunoreactivity was seen in all the specimens of HCC and adjacent non-tumorous tissues.Immunoreactivity intensity was higher in adjacent non-tumorous tissues than in HCC (χ2=9.184,P＜0.01).The mean scores of M VD-CD105 were also higher in adjacent non-tumorous tissues than in HCC.The levels of expression and distribution of MVD-CD105 in HCC were associated with tumor metastasis and TNM staging (P＜0.01).The levels of expression and distribution of MVD-CD105 in adjacent non-tumorous tissues were associated with TNM staging and 2-year survival rate (P＜0.01).Conclusions CD105 showed no specificity in labeling MVD of HCC specimens.The higher level of expression and distribution of MVD-CD105 in HCC was associated with local tumor metastasis and progression.CD105 cannot be used as a target for anti-angiogenesis therapy for HCC.
