Effects of Leptin on the expression of CD80, CD86 and HLA-DR in human monocytes

VernacularTitle:Leptin对人单核细胞CD86和HLA-DR表达的影响
Author: Liping SHI ; Zhihua LIU ; Xiuping ZHOU ; Daqing YANG ; Linsheng LEI
Publication Type:Journal Article
Keywords: Leptin/PD; Antigens,CD86/ME/DE; HLA-DR antigens/ME/DE; Monocytes/ME/DE/IM
From: Journal of Chinese Physician 2011;13(10):1313-1315
CountryChina
Language:Chinese
Abstract: Objective To study the effects of Leptin on the expression of CD86 and HLA-DR in human monocytes.Methods The expression of CD86 and HLA-DR in THP-1 Cells and human primary monocytes were detected by flow cytometry.Results Expression of CD86 and HLA-DR in THP-1 cells was significantly increased after treatment with high-dose Leptin ( CD86Untreated group:8.78 ± 1.66,CD86leptin10:50.76 ± 4.29,CD86leptin100:95.20 ± 4.90; HLAUntreated group:20.75 ± 2.12,HLAleptin10:102.14 ± 5.75,HLAleptin100:104.32 ± 4.75;).The similar results were observed in human primary monocytes ( CD86Untreated group:17.91 ± 1.78,CD86leptin100:48.80 ± 3.60; HLAUntreated group:34.10 ± 2.76,HLAleptin100:88.86 ± 3.53).Conclusions By up-regulating CD86 and HLA-DR expression,Leptin might enhance the ability to present antigen in THP - 1 cells and human monocytes.