Association of interleukin-23 receptor gene polymorphisms with susceptibility and phenotypes of inflamumatory bowel diseases in Jiangsu Han population
10.3760/cma.j.issn.0578-1426.2011.11.009
- VernacularTitle:江苏汉族人群白细胞介素-23受体基因多态性与炎症性肠病及其表型的关系
- Author:
Xiaodan ZHAO
;
Fangcheng SHEN
;
Hongjie ZHANG
;
Xiuyun SHEN
;
Yamin WANG
;
Xiaozhong YANG
;
Huiming TU
;
Yahong TAI
;
Ruihua SHI
- Publication Type:Journal Article
- Keywords:
Receptors,interleukin-23;
Polymorphism,single nucleotide;
Inflammatory bowediseases
- From:
Chinese Journal of Internal Medicine
2011;50(11):935-941
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the possible association of interleukin-23 receptor(IL-23R) polymorphisms with the susceptibility and phenotype of inflammatory bowel diseases (IBD) in Jiangsu Han population.MethodsWe genotyped 178 IBD patients including 135 patients with ulcerative colitis ( UC),43 patients with Crohn's disease (CD),and 134 headthy controls for rs11805303,rs1343151,rs11465804,rs11209032,rs17375018,rs11465788.ResultsComparing with the controls (50.4％ ),there was a significant increase in the carriage of the T allele of rs11805303 in UC (60.4％) ( P =0.020).In genotypephenotype correlation of rs17375018 in UC,clinical severity(UCDAI) was associated with the prevalence of the G allele showed a trend to mild activity.Genotype polymorphisms of rs17375018A was observed more in younger than 25 in the genotype-phenotype correlation in CD(41.7％ vs 22.0％,P =0.050,OR =2.532,95％ CI 0.988-6.494),while rs11805303 was associated with age at diagnose and disease lesion (P =O.039 and 0.044).The risk of extra intestinal manifestation in rs17375018A allele carriers was lower (23.1％ vs46.7％,P=0.040,OR =2.917,95％CI 1.027-8.283).ConclusionsWe confirmed the susceptibility of rs11805303polymorphisms with UC and first demonstrated the genotype-phenot correlation of rs11805303,rs17375018 with UC,CD in Jiangsu Han population.
