The correlation of notch-1 expression and comprehensive analysis with prognosis in small cell lung cancer
10.3760/cma.j.issn.1008-6315.2011.10.033
- VernacularTitle:小细胞肺癌Notch-1表达相关性及预后分析
- Author:
Weihua XIAO
;
Haifen MA
;
Junqiang LI
;
Jihong YU
;
Ji HE
;
Guorong CHEN
- Publication Type:Journal Article
- Keywords:
Lung cancer;
small cell lung cancer;
Notch-1;
Immunohistochemistry;
Prognosis
- From:
Clinical Medicine of China
2011;27(10):1100-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of Notch-1 expression in small cell lung cancer(SCLC) and non-small cell lung cancer(NSCLC),and analyze the role of it in prognosis.Methods SP immunohistochemistry was used to detect the expression of Notch-1 antibody in 43 of SCLC and 40 of NSCLC tissues.Further analysis was carried out to interpret the association of Notch-1 antibody expression with clinicopathological features,lymph node metastasis and prognosis in SCLC.Results The positive rate of Notch-1 expression was 20.93％ ( 9/43 ) in SCLC,while 65.00％ ( 26/40 ) in NSCLC.The expression of Notch-1 antibody was associated with clinical stage and lymph node metastasis ( x2 =5.42,P ＜ 0.05 ; x2 =4.88,P ＜ 0.05respectively),but was not associated with age,sex,tumor location,tumor size ( Ps ＞ 0.05 ).Compared with NSCLC,the expression rates of Notch-1 antibody were significantly higher in SCLC ( x2 =16.50,P ＜ 0.05 ).Kaplan-Meier survival analysis indicated that the survival time of patients with positive Notch-1 expression was significantly longer than that of patients with negative staining( x2 =19.87,P ＜ 0.05 ).Cox regression analysis showed that Notch-1 antibody could significantly reduce the risk of death in patients with SCLC.Conclusion The positive expressions of Notch-1 were significantly different in SCLC and NSCLC,which linked to the clinicalstage,lymph node metastasis and poor prognosis.Accordingly,the expression of Notch-1 may have good value in diagnosis and prognosis.
