The Relationship between Microalbuminuria and Coronary Artery Stenosis or Inflammatory Markers in Patients with Angina Pectoris.
- Author:
Dong Goo KANG
1
;
Myung Ho JEONG
;
Sang Yup LIM
;
Kyung Ho YUN
;
Kye Hun KIM
;
Sang Hyun LEE
;
Yeon Sang LEE
;
Young Joon HONG
;
Hyung Wook PARK
;
Ju Han KIM
;
Young Keun AHN
;
Nam Ho KIM
;
Jeong Gwan CHO
;
Soon Pal SUH
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
- Publication Type:Original Article
- Keywords: Albuminuria; Inflammation; Coronary disease
- MeSH: Albuminuria; Angina Pectoris*; Blood Glucose; C-Reactive Protein; Coronary Artery Disease; Coronary Disease; Coronary Stenosis*; Coronary Vessels*; Fasting; Homocysteine; Humans; Inflammation; Leukocytes; Male; Monocytes; Mortality; Percutaneous Coronary Intervention; Risk Factors
- From:Korean Circulation Journal 2005;35(1):49-54
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND AND OBJECTIVES: Microalbuminuria is associated with increased cardiovascular risk factors and mortality. The aims of this study were to clarify the relationship between the spot urine albumin-creatinine ratio (ACR) and coronary artery stenosis on diagnostic coronary angiograms and to investigate its association with inflammatory markers. SUBJECTS AND METHODS: One hundred thirteen consecutive patients, who underwent a diagnostic coronary angiogram, between April 2004 and July 2004, were divided into two groups: group I (n=89, 58+/-1 2 years, 6 1 male, no microalbuminuria) and group II (n=24, 65+/-10 years, 14 male, microalbuminuria). Microalbuminuria was diagnosed when the ACR was between 30 and 300 mg/g.cr. RESULTS: The mean age was higher in group II than group I (58+/-1 2 vs. 65+/-1 0 years, p=0.013), and group II also showed higher levels of white blood cell (7.0+/-2.4 vs. 9.5+/-4.1 x 103/mm3, p=0.009), monocyte (0.4+/-0.2 vs. 0.5+/-0.2 x 103/mm3, p=0.039), homocysteine (8.8+/-3.5 vs. 10.8+/-4.1 micro mol/L, p=0.02) and fasting plasma glucose (126.1+/-33.6 vs. 183.7+/-75.3mg/dL, p=0.001), and more frequent higher value of high sensitivity C-reactive protein (>0.5mg/dL) (16.9 vs. 66.7%, p<0.001 ) compared with those of group I. There was a correlation between the ACR and all the inflammatory markers tested. Significant coronary lesions, requiring percutaneous coronary intervention, were more frequently detected in group II than in group I (50.6 vs. 75%, p=0.032). CONCLUSION: The ACR was associated with significant coronary artery disease and the inflammatory markers.
