Clinical significance of heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction

VernacularTitle:心脏型脂肪酸结合蛋白在急性心肌梗死早期诊断中的临床意义
Author: Yongsheng XING ; Minglei HAN ; Pengfei WANG ; Weidong JIN ; Shuhan YANG ; Cheng WANG ; Yonglan HOU ; Yanbin LIU ; Zhen LIU
Publication Type:Journal Article
Keywords: Myocardial infarction; Early diagnosis; Heart-type fatty acid-binding protein
From: Chinese Journal of Postgraduates of Medicine 2011;34(25):18-20
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the clinical significance of heart-type fatty acid-binding protein (H-FABP) in acute myocardial infarction(AMI) patients. MethodsThe level of H-FABP was assayed within 30 min, 1 h, 2 h, 4 h,6 h and 12 h by enzyme linked immunosorbent assay (ELISA) in 46 AMI patients, and cardiac troponin Ⅰ(cTnⅠ) and creatinine kinase(CK-MB) also was assayed by routine method.The diagnostic accuracy was compared among different methods. ResultsThe diagnostic accuracy of H-FABP[95.7％ (44/46)] was significantly higher than cTnⅠ[65.2％(30/46)] and CK-MB[41.3％ (19/46)](P ＜0.05). The levels of H-FABP, cTnⅠ and CK-MB significantly increased after AMI onset 4,6,12 hrespectively. ConclusionThe diagnosticaccuracy of H-FABP is higher and can be used as a parameter for the early diagnosis of AMI.