Endoscopic ultrasound guided fine needle aspiration in combination with flow cytometry in the diagnosis of gastrointestinal lymphoma
10.3760/cma.j.issn.0254-1432.2012.11.005
- VernacularTitle:超声内镜引导下细针穿刺联合流式细胞术诊断胃肠淋巴瘤初探
- Author:
Ying XU
;
Shuxian ZHANG
;
Shubei WANG
;
Lu XIA
;
Xiangqin WENG
;
Tingjun YE
;
Qi ZHU
;
Yunwei SUN
- Publication Type:Journal Article
- Keywords:
Gastrointestinal neoplasms;
Lymphoma;
Endoscopy;
Flow cytometry;
Aspiration biopsy,fine-needle
- From:
Chinese Journal of Digestion
2012;32(11):735-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of endoscopic ultrasound guided fine needle aspiration (EUS-FNA) in combination with flow cytometry (FCM) in lymphoma.Methods From January 2011 to December 2011,the cases of suspicious lymphoma with EUS-FNA examination at Shanghai Ruijin Hospital were retrospectively analyzed.The final diagnosis was according to pathological diagnosis of specimen from the surgery and follow up results.The sensitivity,specificity and accuracy of EUS-FNA combined with FCM in lymphoma diagnosis were initially analyzed.Results A total of 14 suspicious lymphoma patients were collected,eight cases were diagnosed as lymphoma by pathological examination of specimen from the surgery or.tissue from aspiration,four cases were non-lymphoma lesions and two cases still had no final diagnosis.The sensitivity and specificity of FCM alone in lymphoma diagnosis were 4/8 and 4/4 respectively.Six cases of lymphoma were detected by EUS-FNA with FCM.The sensitivity,specificity and accuracy of EUS FNA combined with FCM were 6/8,6/6 and 10/12 respectively.Conclusion EUS-FNA combined with FCM has better diagnostic value in lymphoma,especially for gastrointestinal lymphoma and those surrounding deep lesions.
