Characteristic analysis of monoblastic sarcoma cutis preceding acute monoblastic leukemia

VernacularTitle:以皮肤单核细胞肉瘤为首发表现的急性单核细胞白血病的特征研究
Author: Zhengjuan ZHAO ; Yinghong YANG ; Wei TIAN ; Yuying WANG ; Lihang LIN
Publication Type:Journal Article
From: Chinese Journal of Dermatology 2012;45(10):752-753
CountryChina
Language:Chinese
Abstract: A 1-year-old boy developed multiple skin-colored nodules on the forehead and extremities when he was 4 months old.Physical examination revealed that his general condition was well with no hepatomegaly,splenomegaly,lymphadenectasis,testicle abnormality or gingival hypertrophy.Pathologically,the epidermis was normal,while the dermis and subcutaneous tissue were diffusely infiltrated with medium-to large-sized deformed cells,which had a small amount of cytoplasm,oval nucleus,irregular shape and fine chromatin.Some infiltrating cells had nuclear groove and nucleoli.Immunohistochemical studies showed that the tumor cells were positive for S-100 protein,CD56,CD123,CD163,CD68,Ki-67 (40％),weakly positive for CD4 (some),but negative for myeloperoxidase,CD1,CD21.Bone marrow smears showed a 24.5％ infltration by monoblasts and promonocytes.A diagnosis of monoblastic sarcoma cutis preceding acute monoblastic leukemia was made.