The value of NT-probrain natriuretic peptide in predicting the severity of the coronary lesions in old patients with non-ST elevation acute coronary syndromes
10.3760/cma.j.issn.0254-9026.2012.10.014
- VernacularTitle:氨基末端脑钠肽前体对老年非ST段抬高型急性冠脉综合征患者病变程度的预测作用
- Author:
Yigang YIN
;
Li ZHU
;
Yin REN
;
Xiaobin WANG
;
Zhongbao RUAN
;
Jie LIN
;
Jianmin LI
;
Bin WANG
- Publication Type:Journal Article
- Keywords:
Natri uretic peptide,brain;
Coronary artery disease
- From:
Chinese Journal of Geriatrics
2012;31(10):878-880
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between NT-probrain natriuretic peptide (NT-proBNP) levels and the degree of coronary artery stenosis in elderly patients with non-ST elevation acute coronary syndromes (NST-ACS).Methods The levels of NT-proBNP were determined in 258 elderly patients with NST-ACS divided into 3 quartile groups based on the degree of coronary artery stenosis,and 62 normal controls.And NT-pro BNP were compared among 4 groups.Results The serum levels of NT proBNP were increased in the NST-ACS patients with single,two or three-artery lesion compared with normal controls [(197.3±80.2)ng/L,(381.7±73.5)ng/L,(496.5± 99.8) ng/L vs.(68.2 ± 36.1) ng/L].The level of NT proBNP was enhanced along with increasing severity coronary artery disease (all P＜0.01).And with aging,the NT-proBNP levels were rising [aged＞60-69 years:(182.34±69.13) ng/L; aged≥70-79 years:(302.68±87.51)ng/L; aged≥80 years:(482.09±82.2)ng/L] (all P＜0.01).Conclusions The NT-proBNP level is enhanced along with aging and increasing severity of coronary artery stenosis in elderly NST-ACS patients.
