Clinical significance of antibody to proliferating cell nuclear antigen in patients with systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2012.10.009
- VernacularTitle:抗增殖细胞核抗原抗体在系统性红斑狼疮中的临床意义
- Author:
Jing WANG
;
Jinwei CHEN
;
Jiesheng GAO
;
Fen LI
;
Jing TIAN
;
Jinfeng DU
;
Xi XIE
;
Ni MAO
;
Peijun WU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Proliferating cell nuclear antigen;
Anti-PCNA antibody
- From:
Chinese Journal of Rheumatology
2012;16(10):684-687
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance and diagnostic value of anti-proliferating cell nuclear antigen (PCNA) antibodies.Methods A retrospective analysis was conducted for the diagnoses and clinical features of 102 patients with anti-PCNA antibodies.Line immunoassay was used to detect anti-PCNA antibody of 536 systemic lupus erythematosus (SLE) patients.Possible relationship between anti-PCNA anti-body and clinical features and other antibodies in SLE were analyzed.Comparisons between groups were performed by t-test or x2 test.Results In the 102 patients with anti-PCNA antibodies,49 had SLE (48.0％).Other disorders associated with anti-PCNA antibodies included primary Sj(o)gren's syndrome(24.5％),systemic sclerosis (12.7％),primary biliary cirrhosis (3.9％),auto-immune thyroiditis (6.9％),polymyositis/dermatomyositis (2.0％) and hepatitis C virus infection (1.0％).9.1％ of SLE patients showed positive anti-PCNA antibody.Compared with those SLE patients with negative anti-PCNA antibody,the occurrences of rash,neuropsychiatric SLE,renal involvement was significantly higher in the anti-PCNA positive patients.In addition,the SLEDAI score was significantly higher in the latter.The positive rates of anti-Rib-P,anti-dsDNA,anti-Ro52,anti-RNP/Sm were higher in patients of SLE with positive anti-PCNA antibody.Conclusion Sera anti-PCNA antibody is not specific for SLE and it is associated with the occurrences of rash,Raynaud's phenomenon,neuropsychiatric SLE,renal involvement and positive rates of anti-Rib-P,anti-dsDNA,antiRo52,anti-RNP/Sm.In addition,anti-PCNA antibody is associa-ted with the disease activity of SLE.
