The tendency of PAI-1 and TAFI levels in STEMI patients after thrombolytic treatment and its predictive value to restoration of coronary perfusion
10.3760/cma.j.issn.1671-0282.2011.12.023
- VernacularTitle:血浆PAI-1和TAFI的变化对STEMI患者静脉溶栓治疗后血管再通的预测价值
- Author:
Peiyi LIN
;
Xiaohui CHEN
;
Huilin JIANG
;
Jieru CHEN
;
Xuhong ZHOU
;
Ying FENG
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
STEMI;
Thrombolystic therapy;
rt-PA;
TAFI;
PAI-1;
Recanalization/revascularization;
predictive value
- From:
Chinese Journal of Emergency Medicine
2011;20(12):1321-1324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the tendency of the plasma concentration of plasminogen activator inhibitor type-1 (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI) before and after thrombolytic treatment of acute ST elevation myocardial infarction (STEMI) and to explore their recanalization predictive value of PAI-1 and TAFI for acute myocardial infarction patients with thrombolytic treatment.Methods Sixty patients,who received thromobolytic treatment from January 2007 to March 2009,were prospectively recruited.The blood sample were collected within 2 hours of thromobolytic treatment ( 0,0.5 h,1 h,1.5 h and 2 h).The plasma concentration of TAFI and PAI-1 were test by ELISA.16 healthy people were recruited as control group.Results The plasma levels of PAI-1 in STEMI patients before thrombolytic treatment were higher than those of Control group ( P ＜0.01 ),however the same significant change of TAFI level was not seen.The levels of TAFI were no significant difference before and after thrombolytic therapy during whole observation periods.However,the level of PAI-1 increased at 1.5 h and 2 h after thrombolytic therapy (P ＜ 0.01 ).The plasma PAI-1 levels of no - revascularigation group at 2 h after thrombolytic therapy were significant higher than that in revascularization group ( P ＜ 0.05 ).The levels of TAFI were not significantly different between two groups (P ＞ 0.05).Conclusions The decrease of plasma PAI-1 from high level within 2 hours after thrombolysis treament may be exploring the predictive value for revascularization.The tendency of TAFI can' t forecast the result of revascularization.
