Wnt signaling pathway antagonist SOX17 in cancer
10.3760/cma.j.issn.1673-422X.2012.10.005
- VernacularTitle:Wnt信号通路抑制因子SOX17在肿瘤中的研究
- Author:
Sufen CUI
;
Zhizhi WANG
;
Lingling ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
SOX17 protein;
Wnt signaling pathway
- From:
Journal of International Oncology
2012;39(10):735-737
- CountryChina
- Language:Chinese
-
Abstract:
SOX17,a member of the SOX family of transcription factors,is conserved in many species and plays an important role in the formation of embryo endoderm.A number of studies have found that SOX17 gene expression is silenced or decreased might be due to promoter bypermethylation,which plays a vital role in tumorigenesis and tumor progression,and may contribute to aberrant activation of canonical Wnt signaling pathway in several human malignant tumors.
