MicroRNA-19 and neoplasms

VernacularTitle:miR-19与肿瘤
Author: Jikui SUN ; Zhifan JIA ; Weidong YANG
Publication Type:Journal Article
Keywords: miR-19; Neoplasms; Lymphoma; Leukemia
From: Journal of International Oncology 2012;39(9):643-646
CountryChina
Language:Chinese
Abstract: The miR-17-92 cluster,consisting of six individual microRNAs,including miR-17,miR-20a,miR-18a,miR-19a,miR-19b and miR-92a-1,is a kind of typical oncogenic polycistron microRNA.MiR-19 (containing miR-19a and miR-19b),as the key oncogenic component in miR-17-92 cluster,is overexpressed in human cancers including lymphomas,leukaemia,lung cancer,breast cancer and multiple myeloma,and has been one of research focus in recent years.It is found that miR-19 promotes tumor growth,invasion and metastasis through negative regulation of target genes such as PTEN,PP2A,Bim,SOCS1,and is correlated strongly with PI3K-AKT-mTOR pathway.MiR-19 plays an important role in tumor genesis and development.