Fractionated stereotactic radiotherapy for recurrent small cell lung cancer brain metastases after whole brain radiotherapy
10.3760/cma.j.issn.1004-4221.2012.01.007
- VernacularTitle:小细胞肺癌脑转移全脑放疗失败后挽救性分次立体定向放疗疗效分析
- Author:
Xiangpan LI
;
Jianping XIAO
;
Xiujun CHEN
;
Xuesong JIANG
;
Ye ZHANG
;
Yingjie XU
;
Fukui HUAN
;
Hao FANG
;
Bao WAN
;
Yexiong LI
- Publication Type:Journal Article
- Keywords:
Carcinoma,small-cell lung;
Neoplasms metastases,brain;
Radiotherapy,stereotactic
- From:
Chinese Journal of Radiation Oncology
2012;21(1):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective Evaluation the Fractionated Stereotactic Radiotherapy (FSRT) for the patients with small-cell lung cancer (SCLC) after the whole brain radiotherapy (WBRT) failure.Methods We retrospectively analyzed 35 patients with brain metastases from small-cell lung cancer treated with linear accelerator FSRT after the WBRT failure. Multivariate analysis was used to determine significant prognostic factor related to survival.ResultsThe following-up rate was 100％.The median following-up time was 11 months.The median over-all survival (OS) time was 10.3( 1 -30) months after FSRT.Controlled extra cranial disease was the only identified significant predictor of increased median OS time (χ2 =4.02,P =0.045 ).The median OS time from the diagnosis of brain metastasis was 22 (6 - 134 )months.14 patients died from brain metastasis,14 from extra-cranial progression,1 from leptomeningeal metastases,and 3 from other causes. Local control at 6 months and 12 months was 91％ and 76％,respectively.No significant late complications.New brain metastases outside of the treated area developed in 17％ of patients at a median time of 4(2 -20) months; all patients had received previous WBRT.ConclusionsFractionated stereotactic radiotherapy was safe and effective treatment for recurrent small-cell lung carcinoma brain metastases.
