Trichogerminoma: a case report
10.3760/cma.j.issn.0412-4030.2012.01.012
- VernacularTitle:毛胚瘤一例
- Author:
Hao CHEN
;
Yanning XUE
;
Yiqun JIANG
;
Xuesi ZENG
;
Jianfang SUN
- Publication Type:Journal Article
- Keywords:
Trichogerminoma;
Skin manifestations;
Case reports [Publication Type ]
- From:
Chinese Journal of Dermatology
2012;45(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
A case of benign follicular neoplasm-trichogerminoma-is reported.A 48-year-old man presented with a 10-year history of asymptomatic subcutaneous nodule in the chest.Histological examination revealed a well-circumscribed lesion composed of variously sized lobuli and cysts in the deep dermis and separated from the surrounding tissue by a fibrous capsule.Most lobuli consisted of concentrically arranged clear cells in the central area and basophilic cells in a palisade arrangement in the peripheral area.The tumor cells displayed a multi-directional differentiation toward hair bulb,inner root sheath,outer root sheath and infundibulum of hair follicles.Immunohistochemically,the tumor cells expressed AE1/AE3,CK5/6 and CK17,but were negative for CK20 or CK7.There was a sharp contrast in immunohistochemical findings between the central clear cells and peripheral basophilic cells.Based on the histological and immunohistochemical features,a diagnosis of trichogerminoma was made.
