Influence of organic anion transporting polypeptide (SLCO1B1 and SLCO1B3) genetic polymorphisms on mycophenolic acid in Chinese kidney transplantation patients

VernacularTitle:有机阴离子转运体1B1和1B3基因多态性对肾移植受者血麦考酚酸浓度的影响
Author: Duojiao WU ; Ming XU ; Xuanchuan WANG ; Qunye TANG ; Ruiming RONG ; Tongyu ZHU
Publication Type:Journal Article
Keywords: Kidney transplantation; Mycophenolic Acid; Organic anion-transporting polypeptide; Polymorphism,single nucleotide
From: Chinese Journal of Organ Transplantation 2011;32(7):393-395
CountryChina
Language:Chinese
Abstract: Objective To analyze the relationship between the genetic polymorphisms of organic anion transporting polypeptide (SLCO1B1 and SLCO1B3) and mycophenolic acid ( MPA)pharmacokinetics in Chinese kidney transplant recipients. Methods Gene mutations (SLCO1B3T334G, SLCO1B1 A338G) were detected in 68 recipients by PCR-LDR. The plasma samples were collected and blood concentration of MPA was measured on the 28 th day after transplantation. The area under the curve (AUC)0-12 of MPA in different genotype recipients was compared to analyze the correlation between single nucleotide polymorphisms (SNPs) and MPA pharmacokinetics. Results MPA AUC0-12 was higher in SLCO1B3 T334G GG carriers group than in TT carriers [(54. 54 ±14.40)vs(37.30±12.88)mg·h·L-1,(P=0.052)].However,there was no difference in MPA AUC0-12 among each genotype of SLCO1B1 A338G (P>0. 05). Conclusion Genetic polymorphisms of SLCO1B3 affect interindividual variety in plasma MPA concentration in Chinese kidney transplantation recipients.