A clinical observation of pulmonary function changes following three-dimensional conformal radiation therapy in patients with non-small cell lung cancer
10.3760/cma.j.issn.1008-1372.2011.04.004
- VernacularTitle:肺癌患者三维适形放疗前后肺功能的动态变化及与放射性肺炎发生的关系研究
- Author:
Fengyu LI
;
Xiufang LIU
;
Shuqi WANG
;
Guohong JIA
;
Hai ZHANG
;
Li WAN
;
Chengbo REN
- Publication Type:Journal Article
- Keywords:
Lung neoplasms/RT/PP;
Respiratory function tests;
Pneumonia/CO;
Radiotherapy,conformal/AE
- From:
Journal of Chinese Physician
2011;13(4):444-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationships among pulmonary function,DVH and acute radiation pneumonitis after three-dimensional conformal radiation treatment in patients with non-small-cell lung cancer.MethodsPulmonary function tests were conducted on 68 inoperable patients (male 42,female 26,median age 52,KPS≥80) before and after three months radiotherapy respectively.After 3 months of follow-up,radiation pneumonitis were graded,and V20,V30 and MLD were derived from dose volume histogram (DVH).ResultsAll patients were treated with radiotherapy at the irradiation dose of 60～70Gy.Acute radiation pneumonitis occurred in 24 patients with 11 Grade Ⅰ,7 Grade Ⅱ,3 Grade Ⅲ,3 Grade Ⅳ.There were no significant difference between the pre-irradiation and the three months after irradiation for FVC (P＞0.05).But there were significant different between pre-irradiation and three months after irradiation for FEV1.0 and DLCO (P＜0.05).V20,V30 and MLD were observed in patients treated with high radiation pneumonitis.ConclusionsThere were close relationships among pulmonary function,DVH and radiation pneumonitis in patients with non-small cell lung cancer.
