Pathological changes of soft tissues and transforming growth factor beta 1 expression in radiation masseter injury models
10.3969/j.issn.1673-8225.2011.15.044
- VernacularTitle:放射性咀嚼肌损伤模型软组织病理改变及转化生长因子β1的表达
- Author:
Zongze SHEN
;
Jianjin ZHENG
;
Muyun JIA
;
Gang DONG
;
Tao LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2011;15(15):2842-2846
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Long-term radioactive ray accumulation leads to surrounding tissues fibrosis accompanied by limitation of mouth-opening, which seriously affects life quality of tumor patients. OBJECTIVE: To observe pathological change of soft tissues in rats with radiation masseter injury and the level of transforming growth factor β1 (TGF-β1) mRNA expression in vivo.METHODS: A total of 30 Wistar rats were randomly divided into control group (n=10) and radiated group (n=20). Radiated group were radiated with linear accelerator at a dose of 40 Gy. The pathological changes of vessels were observed under light microscope and electron microscope and expression of TGF-β1 was detected by RT-PCR. RESULTS AND CONCLUSION: The microvessel density of radiated group was obviously decreased than that of the control group (P < 0.01), but the mRNA expression of was higher than that in the control group (P < 0.01). It suggests that radiated injury can induce fibrosis to repair the radiated injury.
