Foxm1 research progress in cell cycle and tumor
10.3760/cma.j.issn.1673-422X.2011.05.004
- VernacularTitle:Foxm1在细胞周期和肿瘤中的研究进展
- Author:
Yongfeng LI
;
Shize ZHU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Cell cycle;
Transcription factors
- From:
Journal of International Oncology
2011;38(5):332-335
- CountryChina
- Language:Chinese
-
Abstract:
Forkhead Box m1 ( Foxm1) is a component of the Fox transcription factor family. It is only detected in proliferating cells, but disappears when cells enter into their terminal differentiation phase. Foxml is closely related to cellular growth mainly through inhibiting cyclin-dependent kinase(cdk) inhibitors to influence cell proliferation. It also participates in growth hormone mediated cell multiplication. The overexpression of Foxml has been observed in many tumor cell lines and malignant tumors, indicating that Foxml might be an essential proto-oncogene in carcinoaenesis. Upregulation of Foxml is sufficient to induce genomic instability due to loss of heterozygosity and variation of copy numbers. Foxml-induced genomic instability was significantly enhanced and accumulated with increasing cell passages. Foxml might become a new potential target for the treatment human cancer based on future investigations.
