Mechanisms of ginsenoside and oridonin inducing cancer cell apoptosis
10.3760/cma.j.issn.1673-422X.2011.04.008
- VernacularTitle:人参皂苷和冬凌草甲素诱导癌细胞凋亡的作用机制
- Author:
Xiaoji LI
;
Zhikuan MI
;
Zhaoying FU
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Neoplasms;
Drugs,Chinese herbal
- From:
Journal of International Oncology
2011;38(4):263-266
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis plays a critical role in tumor genesis and progression. Induction of cancer cell apoptosis with traditional Chinese medicines is at present a hot topic in the research of cancer therapy. It has been found that many active components of traditional Chinese medicines can induce cancer cell apoptosis; ginsenoside and oridonin are two of them that have been studied relatively thoroughly. The mechanisms that ginsenoside and oridonin induce cancer cell apoptosis include arresting cell cycle progression, up-regulating expression of apoptotic promoting proteins, down-regulating expression of apoptotic inhibiting proteins, and activating caspase cascade.
