Clinical Observation On The CPT-11 Plus 5-FU For treatment Advanced Rectal Cancer

VernacularTitle:伊立替康联合氟尿嘧啶治疗晚期直肠癌
Author: Weijun TANG ; Hongyuan ZOU ; Chunfang PENG
Publication Type:Journal Article
Keywords: Rectal neoplasms; Irinotecan; Fluorouracil; Chemotherapy
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(2):161-162
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy and adverse events of irinotecan (CPT-11) combined with 5-FU in treatment of patients with advanced rectal cancer. Methods 86 patients were randomly divided into FOLFIRI treatment group and IFL treatment group. The efficacy and adverse events were observed. Results There was no statistically significant difference between FOLFIRI treatment group and IFL treatment group in CR、PR、SD and RR(all P ＞ 0. 05). There was also no statistically significant difference between FOLFIRI treatment group and IFL treatment group in adverse events(all P ＞ 0.05). Conclusion Irinotecan in combination with 5-FU was effective and had some tolerable adverse events in treating patients with advanced rectal cancer in both FOLFIRI treatment group and IFL treatment group.