Expression and significance of IGF-Ⅱ and bFGF in adrenal disease
10.3760/cma.j.issn.1008-6706.2011.04.022
- VernacularTitle:胰岛素样生长因子Ⅱ及碱性成纤维细胞生长因子在肾上腺疾病组织中的表达
- Author:
Chulong ZHANG
;
Weilie HU
;
Cheng HUANG
- Publication Type:Journal Article
- Keywords:
Adrenal disease;
Insulin-like growth factor Ⅱ;
Basic fibroblast growth factor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(4):482-484
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expressions and significance of insulin-like growth factor Ⅱ and basic fibroblast growth factor in adrenal disease. MethodsThe experiment was divided into groups of adrenal pheochromocytoma,corticomedullary hyperplasia,cortical adenoma,normal adrenal tissue.Every group was 15 cases.Expression of IGF-Ⅱ and bFGF were detected by immunohistochemistry in adrenal disease. ResultsThere was a significant difference among the four groups(all P＜0.05).IGF-Ⅱ and bFGF expression was higher in adrenal pheochromocytoma tissue than that of corticomedullary hyperplasia and cortical adenoma.In the normal adrenal gland group was low expression or no expression.In each group,IGF-Ⅱ and bFGF protein expression was positively correlated(all P＜0.05).There also was a positive correlation between IGF-Ⅱ and bFGF positive cell and blood pressure in adrenal pheochromocytoma,corticomedullary hyperplasia and cortical adenoma(all P＜0.05). ConclusionIGF-Ⅱ and bFGF protein were closely related to the occurrence and development of human adrenal corticomedullary hyperplasia,cortical adenoma,pheochromocytoma,and played a role in hypertension caused by them.At the same time there was a synergistic effect between the IGF-Ⅱ and bFGF protein in adrenal disease.
