Influence of multidrug resistance polymorphism on CsA-associated hepatotoxicity
10.3760/cma.j.issn.1007-8118.2011.03.015
- VernacularTitle:多药耐药多态性对环孢素急性肝毒性作用的影响
- Author:
Shenghua HAO
;
Xinmin NIE
- Publication Type:Journal Article
- Keywords:
MDR polymorphism;
CsA;
Hepatotoxicity
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(3):228-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of MDR polymorphism on CsA-associated hepatotoxicity. Methods PCR/RFLP was used to analyze the genotypes of MDR exon26 in 187 recipients. CsA-associated hepatotoxicity was evaluated among groups being classified according to the genotypes. Results MDR exon26 takes 3 genotypes:CC,CT and TT, in the following ratio: 29.4%(55/187), 40.1%(75/187), 30. 5%(57/187). Among the same range of whole blood CsA concentration, incidence of CsA-associated hepatotoxicity is markedly higher in the CT/TT group than that in in patients with CsA-associated hepatotoxicity between the CC group and the CT/TT group is signifiimportant role in the development of CsA-associated hepatotoxicity.
