Correlation between polymorphism of angiotensin converting enzyme gene and hypertensive disorder complicating pregnancy in Chinese population:a meta-analysis

VernacularTitle:中国人群血管紧张素转换酶基因多态性与妊娠期高血压疾病相关性的meta分析
Author: Hong YU ; Tingfeng LU ; Yang SHEN ; Mulan REN ; Bei WANG ; Jianqiong ZHANG
Publication Type:Journal Article
Keywords: Hypertension,pregnancy-induced; Peptidyl-dipeptidase A; Polymorphism,genetic; Meta-analysis
From: Chinese Journal of Perinatal Medicine 2011;14(2):92-97
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation between polymorphism of angiotensin converting enzyme (ACE) gene and hypertensive disorder complicating pregnancy (HDP) in Chinese people.Methods The 21 case-control studies on the correlation between polymorphism of ACE gene (genotype DD,DI,Ⅱ) and HDP in Chinese people were analyzed by meta-analysis.The analysis was performed on Review Manager 4.2 software.According to the result of test for heterogeneity,the random effects model was used to calculate the pooled OR value and 95% CI.Results Twenty-one case-control studies were enrolled in this meta-analysis,a total of 1486 HDP cases and 1758 controls were included.The pooled OR values (95% CI) of DD,DI,Ⅱ genotypes of ACE gene polymorphism for HDP risk were 2.60 (1.84-3.67),0.98 (0.76-1.27) and 0.46 (0.32-0.65) respectively.Conclusions Genotype Ⅱ of ACE is a protective gene against HDP and genotype DD is a susceptibility gene for HDP.