Clinicopathological study of thinprep cytologic test on 4234 patients with cervical lesion

VernacularTitle:液基薄层细胞学检测子宫颈病变4234例临床病理分析
Author: Guangfeng CHEN ; Liya HE ; Pingping LIU ; Yuting LI ; Guiying LIU ; Haohe LIANG
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Histocytological preparation techniques; Diagnosis
From: Cancer Research and Clinic 2011;23(3):176-178
CountryChina
Language:Chinese
Abstract: Objective To estimate the clinical value of thinprep cytologic test (TCT) in screening cervical lesion. Methods 4234 TCT samples were interpreted according to the Besthesda System (TBS), 272positive cases (ASC-US or above) were taken colposcopic examination and biopsy. Results The coincidence of the results between TCT and biopsy in low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), squamous cell carcinoma (SCC), adenocarcinoma (AC) were 85.71%(12/14), 100 % (20/20), 75 % (3/4) and 100 % (2/2), respectively. The positive rates of over ASC-H by TCT and of over CIN Ⅰ by biopsy were 23.16 % (63/272) and 24.26 % (66/272), respectively. There is no difference between two positive rates (x2 = 0.868, P = 0.581). Conclusion TCT and histopathological diagnosis had a high coincidence, a combination of both can greatly enhance HSIL and cervical cancer and reduce the incidence of missed diagnosis. TCT would be a rapid and convenient method for screening cervical cancer.