Effect of mifepristone on the expression of β-endorphin the ectopic focus of adenomyosis
10.3760/cma.j.issn.1008-6706.2011.09.007
- VernacularTitle:米非司酮对子宫腺肌病异位病灶组织β-内啡肽表达的影响
- Author:
Shaoguang WANG
;
Xueqiang JIANG
- Publication Type:Journal Article
- Keywords:
Adenomyosis;
Dysmenorrhea;
β-endorphin;
Mifepristone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(9):1168-1169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of mifepristone on the expression of β-endorphin in the ectopic focus of adenomyosis.Methods The expression of β-endorphin was measured by the immunochemistry method.Results During proliferative phase and secretory phase,the β-endorphin of mild dysmenorrhea were higher than that of midrange dysmenorrhea(t=2.672,2.711,all P＜0.05),the β-endorphin of midrange dysmenorrhea was higher than that of severe dysmenorrhea(t=2.341,2.365,all P＜0.05),the difference was significant.After being cured by mifepfistone,the expression of β-endorphin in the ectopic focus of adenomyosis was higher than that of control group (t=2.478,2.356,all P＜0.05),still lower than that of normal endometrial tissue,(t=2.123,2.233,all P＜0.05),the difference was significant.Conclusion The expression of β-endorphin in the ectopic focus of adenomyosis decreased significandy accompanied with the aggravation of the dysmenorrhea,and the mifepfistone could upregulate the β-endorphin and relieve the dysmenorrhea.
