The expression of β2 integrins and L - selectin on acutelymophocytic leukemic cells and its clinical implications
- VernacularTitle:急性淋巴细胞白血病细胞β2整合素及L-选择素的表达与意义
- Author:
Xiuzhen TONG
;
Yunxian CHEN
;
Wende HONG
;
Shaokai LUO
;
Aihua PENG
- Publication Type:Journal Article
- Keywords:
Leukemia,lymphocytic,acute;
Cell adhesion molecules;
Flow cytometry
- From:
Chinese Journal of Pathophysiology
2000;16(12):1310-1312
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: To investigate the expression of adhesion molecule β2 integrins (CD11a、 CD11b) and L-selectin(CD62L )on Acute Lymophocyte Leukemia(ALL) cells and its Clinical Implications. Adhesion molecules CD11a、CD11b、 CD62L of 45 ALL patients and 25 health people were measured by flow - cytometric analysis. RESULTS :①CD11a and CD11b expression were lower on ALL cells than the normal hematopoietic cells. The rate of low expression was 100% for CD11b, 50% for CD11a,respectively. CD62L expression were higher on ALL cells than the normal hematopoietic cells.②The CD11a was lower expressed on B - ALL than T- ALL. CD62L was higher on T- ALL than B- ALL. ③The expression of CD11a in the invasion group was much higher than that in the non - invasive group( P < 0.05).④The levels of CD11a,CD11b were returned to normal levels at remission. CONCLUSION: These results suggest that there are abnormalities in the expression of cell adhesion molecules in ALL which may help identify ALL subtypes and the treatment effect.
