Relationship between activity of matrix metalloproteinases-2and invasion, metastasis of breast cancer
- VernacularTitle:基质金属蛋白酶-2酶活性与乳腺癌浸润转移的关系
- Author:
Yuewu ZHAO
;
Yuanrui HAO
;
Pingzhang YIN
;
Lingfei KONG
;
Baomei WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Metalloproteinases;
Neoplasm metastasis
- From:
Chinese Journal of Pathophysiology
2000;16(12):1295-1297
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate relationship between activity of matrix metalloproteinases - 2 ( MMP - 2, 72 kD) and invasion, metastasis of breast cancer. METHODS: Useing zymography and computer software assisted analysis, the activitive levels of MMP- 2 (72 kD) in tissues from breast cancer were measeured. RESULTS: Mean activitive levels of MMP- 272 kD (13.93 + 3.60) in breast cancer were lower than those in benign disease (21.43 + 8.31), P < 0.05. There was no difference (P > 0.05) in MMP - 2 62 kD + 72 kD of benign and malignant dis ease, but MMP - 262 kD ( 13.83 + 4.53) and MMP - 262 kD/62 kD + 72 kD (0.48) respectively were significantly higher in malignant disease (P < 0.01). It was also found that MMP- 262 kD/62 kD + 72 kD were apparently higher in invasive carcinomas (0.48) and lymph node metastases (0.61), P < 0.01, respectively. CONCLUSION: These results demonstrated that a clear relationship between MMP - 2 activity and the invasion and metastasis of breast carcinoma.
