Expression of tumor suppressor gene-p33/ING1 in colorectal carcinoma
- VernacularTitle:大肠癌中抑癌基因p33/ING1 mRNA的表达及意义
- Author:
Ziqiang WANG
;
Zhimin CAI
;
Peiwu YU
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
2001;23(3):349-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the expression of p33/ING1 and the clinicopathological features in patients with colorectal cancer, and to understand the possible mechanism of p33/ING1 in the oncogenesis of colorectal neoplasms. Methods All samples of normal mucosa and cancer tissues from 52 patients with colorectal cancer were detected for their expression levels of p33/ING1 by RT-PCR. Results A significant decrease in p33/ING1 mRNA expression was found in 30 out of 52(57.7%) colorectal cancer tissues. The results also showed that repression of p33/ING1 expression markedly related to both the Duke's stage and metastasis. Conclusion Down-regulation of p33/ING1 may play an important role in the oncogenesis and development of colorectal carcinoma.
