Study on testicular pathological change, lipid peroxidation and nitric oxide in diabetic rats
- VernacularTitle:糖尿病大鼠睾丸病理变化及脂质过氧化和一氧化氮的改变
- Author:
Guorong CHEN
;
Jianmin LI
;
Yun HU
;
Zhengjie XU
;
Sunzhong MAO
;
Zhouxi FAN
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(5):425-427
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study testicular pathological change and its pathogenesis. METHODS:Testicular structure of alloxan induced diabetic rats was observed under light microscopy (LM)and transmission electron microscopy(TEM). Activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)，nitric oxide synthase(NOS)and content of malondialdehyde (MDA),nitric oxide(NO) were detected biochemically in testicular homogenate. RESULTS:It is manifestated as atrophy of seminiferous tubule and germinal arrest under LM and expansion of mitochondria and smooth endoplasmic reticulum, cytoplasmic inclusion of sertoli cell under TEM.Activity of SOD, GSH-PX decreased while activity of NOS, content of MDA, NO increased in diabetic rats compared with control one. CONCLUSION:Disturbance of spermatogenesis and damage of sertoli cell are the main morphological change of diabetic testis, lipid peroxidation and NO may be involved in it.
