Pathological observation of airway inflammation after neonatal CVB3 inoculation in rats
- VernacularTitle:新生鼠呼吸道感染CVB3致气道炎症的病理学观察
- Author:
Chaoping FANG
;
Feng FANG
;
Qian SHEN
;
Yulian XU
;
Dalie MA
;
Hongxia WEI
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(5):472-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of coxsackie virus B3 on airway tract and lung morphology, and to study the relation between CVB infection and asthma. Methods: We established CVB3 infective model: 5 d neonatal rats inhaled CVB3 by ultrasonic brume. CVB3-IgM was examined 10 d after inoculating of CVB3, and LW/BW, airway tract and lung pathological change 10 d and 30 d after inoculation of CVB3 were observed. Results: Rats from the virus group had higher D of CVB3-IgM than control's (+2s ) and had higher LW/BW 10 d after inoculation of CVB3 than control (P<0.01). Neonatal rats had acute inflammatory changes 10 d after inoculation of CVB3 and persistent changes in morphology and cytology. Conclusion: Neonatal rats virus model is established. Respiratory infection by CVB3 in neonatal rats has persistent changes in airway tract inflammatory and morphology.
