Study on the Pharmacokinetics and Relative Bioavalability of Omeprazole Capsules in Humans
- VernacularTitle:奥美拉唑胶囊人体药代动力学及相对生物利用度研究
- Author:
Liuyi ZUO
;
Guijuan LIU
;
Feng QUI
;
Haixia HE
;
Yuanda ZHOU
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(6):356-357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To study the pharmacokinetics and relative bioavalability of omeprazole capsules in humans.METHODS： 18 male healthy volunteers orally took domestic omeprazole capsules and losec capsulles(used as control)40mg respectively.Blood concentrations of drugs were determined by HPLC.RESULTS： Times to reach the peak levels of omeprazole and losec were （2.10± 0.64） h and （1.88± 0.70） h， the peak plasma concentrations were （895.64± 553.07） ng/ml and （974.67± 554.93） ng/ml and the areas under the drug concentration curves were （1 971.88± 1 220.98 ） ng/（h· ml） and （2 057.60± 1 306.32） ng/（h· ml） respectively.CONCLUSION： The two capsules have the same bioequivalence.
