Activation of nuclear factor kappaB of monocyte in patients with chronic obstructive pulmonary disease
- VernacularTitle:慢性阻塞性肺疾病患者单核细胞NF-κB活性的研究
- Author:
Yong QI
;
Yuepeng GUO
;
Xiaomei YUAN
;
Jinlan LI
;
Lijun MA
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
nuclear factor-κB;
interleukin-8
- From:
Journal of Xinxiang Medical College
2006;23(6):541-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of NF-κB activation in the inflammatory mechanism of chronic obstructive pulmonary disease (COPD).Methods Monocyte were collected from patients with COPD and were cultured,and stimulated with lipopolysaccharide (LPS) ; NF-κB p65 activation was measured by immunohistochemistry; SOD ,MDA and IL-8 and lung function were determined synchronously.Results The NF-κB p65 was induced by LPS in monocyte in all subjects, but it was most markedly done in COPD patients with exacerbateions; There was positive correlation between the NF-κB p65 activation of monocytes and levels of IL-8 and MDA in circulation, but it was negative correlation to SOD.Conclusion NF-κB plays a vital role in regulating product of IL-8 in monocyte in COPD.
