Pharmacokinetics of arbidol capsule in Chinese healthy volunteers
- VernacularTitle:阿比朵尔胶囊在健康人体内的药动学
- Author:
Yingguang SUN
;
Shuhui ZHANG
;
Zhihong QIU
;
Lien HE
;
Jie MA
- Publication Type:Journal Article
- Keywords:
arbidol;
pharmacokinetics;
chromatography,high pressure liquid
- From:
Chinese Journal of New Drugs and Clinical Remedies
2008;27(3):161-164
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the pharmacokinetics of arbidol capsule in Chinese healthy volunteers.METHODS A single oral dose of arbidol capsule 200 mg was given to 20 healthy volunteers respectively.Plasma samples were prepared based on a simple liquid-liquid extraction.The extracted samples were analyzed by HPLC equipped with UV detection.Pharmacokinetic parameters were calculated by 3P87 software. RESULTS The main pharmacokinetic parameters of arbidol were as follows:c(max)(418±s 241)μg·L-1,t(max)(1.3±1.2)h,t(1/2α)(1.9±2.3)h,t1/2β(14±5),hAU0-t(2 633±1 071)μg·L-1,Vc/F(0.7±0.6)L,CL(0.08±0.03)L·h-1,CONLUSION The pharmacokinetics of arbidol capsule in human body accord with two-compartmetn open model.The study will offer the pharmacokinetic parameters for the clinical application of arbidol.
