Preparation of hydroxypropyl-chitosan nano-spheres
- VernacularTitle:羟丙基壳聚糖纳米微粒的制备
- Author:
Yu XIE
;
Xiaoxian SHANG
;
Fengxing JIANG
;
Jingang HU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2008;12(23):4546-4548
- CountryChina
- Language:Chinese
-
Abstract:
Hydroxypropyl-chitosan with substitution degree of 0.56 is prepared by the reaction of chitosan and epoxypropane by controlling condition. The water solubility of modified hydroxypropyl-chitosan is enhanced. When suitable concentration of hydroxypropyl-chitosan water solution responds to certain concentration of sodium polyphosphate based on ion gel method, the hydroxypropyl-chitosan nano-spheres with particle size of 500-700nm are obtained. Transmission electron micrograph shows that the shape of prepared hydroxypropyl-chitosan nano-sphere is uniform.
