Propofol combined with midazolam intravenous sedation anesthesia in pediatric upper gastrointestinal endoscopy
- VernacularTitle:异丙酚复合咪达唑仑静脉麻醉在小儿镇静性上消化道内镜术中的应用
- Author:
Dinghua XIAO
;
Fen WANG
;
Xiaoyan WANG
;
Wuliang TANG
;
Wen OUYANG
;
Shourong SHEN
- Publication Type:Journal Article
- Keywords:
children;
propofol;
midazolam;
upper gastrointestinal endoscopy;
intra-venous anesthesia
- From:
Journal of Central South University(Medical Sciences)
2009;34(7):595-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of propofol combined with midazolam intrave-nous anesthesia in pediatric upper gastrointestinal endoscopy, Methods A total of 497 ASA Ⅰ～Ⅱ patients who received sedative upper gastrointestinal endoscopy were assigned to a children group (2～14 years) and an adults group (18～65 years). The 2 groups were treated with midazolam (0.02～0.03 mg/kg, iv) and propofol (0.6～0.7 mg/s, iv) with an interval of 3～5 minutes. Enterseopy was inserted at light sleep, relaxing muscles, and disappearance of eyelash relaxation. Combining of pro-endoscopy, reaction to intravenous administration, dose of propofol, reaction to en-doscopy, time of returning to consciousness, changes of SpO2, R, HR, and BP, and sedative quali-ty were evaluated. Results Good sedation of the 2 groups after intravenous administration was ob-served. Rate of combining of pro-endoscopy in children was lower (42%) than that in adults (100%). The incidence of restlessness, hyperphasia, temporary decreasing of SpO2, dose of propofol of per kilogram weight, time of returning to consciousness in the children were 82.7%, 17%, 2.4 mg/kg, and (17.5±3.2)min, respectively, which were all higher in the adults [9%,4%,1.4 mg/kg, and (9.5±1.3)min, P<0.01]. HR and BP decreased in the 2 groups, and recovered rapidly after the endoscopy. There was no significant difference between the 2 groups (P>0.05). Conclusion It is safe and effective to use propofol combined with midazolam intravenous sedation anesthesia in pediatric upper gastrointestinal endoscopy.
