Effect of αⅡb Ala477Pro(A446P) mutation of the platelet glycoprotein on the expression of αⅡbβ3 complex
- VernacularTitle:血小板膜糖蛋白αⅡbA477P(A446P)突变对αⅡbβ3复合物表达的影响
- Author:
Xiaoyu YUAN
;
Fangping CHEN
;
Kun XIA
;
Gan FU
;
Zaifu JIAN
;
Qinzhi JIE
;
Guangping WANG
- Publication Type:Journal Article
- Keywords:
Glanzmann thrombasthenia;
integrin αⅡbβ3;
β-propeller;
mutation;
expression
- From:
Journal of Central South University(Medical Sciences)
2009;34(8):712-717
- CountryChina
- Language:Chinese
-
Abstract:
ly reduces the expression of αⅡbβ3 complex on the membrane. This mutation may interfere the formation of αⅡbβ3 complex or impair the proper conformation of αⅡb subunit.
