Prognostic Factors for Survival of 138 Patients with Stage Ⅳ Gastric Cancer

VernacularTitle:138例Ⅳ期胃癌患者预后因素分析
Author: Zhixiang ZHUANG ; Yufeng LU ; Liqin SHEN
Publication Type:Journal Article
Keywords: Gastric cancer; Platinum; Chemotherapy; Prognosis
From: Chinese Journal of Clinical Oncology 2009;36(23):1336-1339
CountryChina
Language:Chinese
Abstract: Objective: To evaluate the prognostic factors of patients with stage Ⅳ gastric cancer. Meth-ods: A total of 138 patients with stage Ⅳ gastric cancer treated with platinum-based chemotherapy were ana-lyzed. Survival rate was estimated by Kaplan-Meier method. The prognostic factors were analyzed by univari-ate (Log rank) and multivariate (Cox model) analysis methods. Results: Univariate analysis and multivariate analysis showed that poor performance status (P=0.001), weight loss (P=0.001), depth of invasion (P=0.000), presence of peritoneal metastasis (P=0.005), more than 1 metastatic site (P=0.029) and elevated total biliru-bin (P=0.018) were independent prognostic factors. According to the outcomes of the Cox model analysis, a formula of the prognostic index was developed. According to the values of PI, 16 patients were categorized as the high-risk group (PI≤9.817), 28 patients were categorized as the moderate-risk group (9.817