CerbB-2 Expression and Significance in Patients with Nasopharyngeal Carcinoma
10.3969/j.issn.1000-8179.2009.23.010
- VernacularTitle:鼻咽癌组织中CerbB-2的表达及其意义
- Author:
Xiangping WANG
;
Changjie HUANG
;
Yongzi ZHAN
;
Jianfeng HUANG
;
Dongyun LI
;
Min PAN
;
Weiying BAO
;
Li LI
;
Yan DENG
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
CerbB-2;
Immunohistochemistry
- From:
Chinese Journal of Clinical Oncology
2009;36(23):1350-1352
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the biological significance of CerbB-2 expression in nasopharyn-geal carcinoma. Methods: The expression of CerbB-2 was detected in 90 nasopharyngeal carcinoma tissues and 22 nasopharyngitis tissues by SP immunohistochemical method. The relationship between CerbB-2 ex-pression and clinicopathological characteristics of nasopharyngeal carcinoma was investigated. Results: The positive expression rate of CerbB-2 protein was 65.56% in nasopharyngeal carcinoma tissues, and 31.82% in nasopharyngitis tissues, with a significant difference (P<0.05). The ratio of expression was 81.0% in patients of N_2 and N_3 lymth node stage, significantly different from that in patients of N_0 and N_1 lymph node stage (52.1%, P<0.05). The expression of CerbB-2 gene was not correlated with age, gender, clinical stage, T stage and distant metastasis of nasopharyngeal carcinoma (P>0.05). Conclusion: There is a high expression of CerbB-2 in nasopharyngeal carcinoma tissues, which might be an important event in the pathogenesis and progression of nasopharyngeal carcinoma.
