Association between Survivin Promoter-31C/G Polymorphism and Genetic Susceptibility to Sporadic Colorectal Cancer
- VernacularTitle:Survivin基因启动子区-31C/G多态性与散发性结直肠癌遗传易感性的关系
- Author:
Jun HUANG
;
Jianping WANG
;
Lei WANG
;
Huanliang LIU
;
Yisheng WEI
;
Meijin HUANG
;
Dianke CHEN
;
Xinhui FU
;
Jing CHEN
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
survivin gene;
single nucleotide polymorphism
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(1):59-63
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the association between -31C/G polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer in southern Chinese population. [Methods] Survivin-31C/G genotypes were determined by polymerase chain reaction-restriction fragment length polymorpbism (PCR-RFLP) in 711 healthy controls and 702 CRC cases. [Results] The number of CRC patients carrying with CC genotype was much higher than those of controls (36.5 % vs. 26.12%, X~2=17.89, P<0.001). Compared with CC genotypes, CG, GG genotypes and G allele carriers had a significantly decreased risk of CRC, with the decrease being 0.61-fold (95% CI=0.46-0.81, P<0.001), 0.52-fold (95% CI=0.38-0.71, P<0.001) and 0.58-fold (95% CI=0.45-0.74, P<0.001), respectively. [Conclusion] Survivin gene -31C/G polymorphism is associated with sporadic CRC risk, the G variant genotypo is the independent protective factors against sporadic CRC in soutbem Chinese population.
