Different effects of imipramine and fluoxetine on depression and anxiety-related behavior induced by stress in adolescent rats
- VernacularTitle:氟西汀和丙米嗪对应激诱导的青幼期大鼠抑郁和焦虑样行为的不同影响
- Author:
Xi XIE
;
Feng SHAO
;
Xiaomin LUO
;
Xiting GUAN
;
Qingxuan MENG
;
Weiwen WANG
- Publication Type:Journal Article
- Keywords:
Depression Stress Adolescent Imipramine Fluoxetine
- From:
Chinese Journal of Nervous and Mental Diseases
2010;36(1):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish chronic stress model of depression in adolescent rats and to examine the effects of different antidepressant treatment on depression and anxiety-related behaviors.Methods Male Wistar rats were given 21-day chronic mild stress (CMS) during their adolescence (postnatal day 30～50, PND30～50).During stress period, rats were treated with fluoxetine (10 mg/kg i.p.) or imipramine (10 mg/kg i.p.), respectively.After stress, rats were tested for behavioral observation using body weight gain, saccharine test, open field and elevated plus-maze (EPM).Results Compared with control/vehicle (n=10) group, stress/vehicle (n=11) group displayed lower weight gain, saccharine preference index and the number of rearing in open field (P<0.05).Antidepressant fluoxetine, but not imipramine reversed anhedonia and the decrease of the number of rearing induced by stress.In addition, compared with early adolescent(PND29) rats, late adolescent (PND52) rats in control/vehicle group exhibited less open arm entries and open arm time, more closed arm time in EPM (P<0.05).Rats in stress/vehicle group showed more open arm entries and less closed arm time than controls(P<0.05).Both fluoxetine and imipramine had no effects on such changes.Conclusions Stress can induce the depression-like behavior in adolescent rats.Fluoxetine, but not imipramine,can effectively reverse anhedonia induced by stress.However, Both antidepressants have no significant effects on stress-induced decrease in developmental increment of anxious behavior during adolescence.These data suggest that chronic mild stress have complicated effects on depressive and anxious behavior in adolescent rats.
