Expression of survivin and caspase-3 in gastric cancer and its clinical significance
- VernacularTitle:胃癌survivin和caspase-3表达及其临床意义
- Author:
Rongbiao YING
;
Jun FENG
;
Jianjun LI
;
Jun YAO
- Publication Type:Journal Article
- Keywords:
gastric cancer;
survivin;
caspase-3;
RT-PCR;
immunohistochemistry
- From:
China Oncology
2010;20(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: Unbalance of apoptosis regulation plays an important role in tumor initiation and progression. Survivin and caspase-3 all take part in the regulation of cell cycle and apoptosis. The expressions of survivin and caspase-3 were detected in the tissues of gastric cancer to explore their association with the carcinogenesis of gastric cancer. Methods: The expressions of survivin and caspase-3 in 79 cases of gastric cancer and 30 cases of adjacent were detected by using reverse-transcription PCR (RT-PCR) and immunohistochemistry. Results: The expressions of survivin mRNA and caspase-3 mRNA were significantly related with the depth of invasion, lymph-node metastasis and TNM stage (P<0.05). The expressions of survivin mRNA and caspase-3 mRNA had significantly differences in gastric cancer (P<0.01). Conclusion: Survivin and caspase-3 are both important factors that cause tumorigenesis of gastric cancer, while survivin may promote the progression of gastric cancer through inhibiting the expression of caspase-3.
