Mechanism of the hepatic ischemia-reperfusion injury
- VernacularTitle:肝脏缺血-再灌注损伤的机制探讨
- Author:
Mingchang SUN
;
Dongchen GAO
- Publication Type:Journal Article
- Keywords:
Ischemia-reperfusion;
injury;
Liver;
Cytokines;
Reactive Oxygen Species
- From:
International Journal of Surgery
2008;35(3):196-199
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia.reperfusion injury of the liver consists of two distinct phases.The early phase occurs within 2 to 4 hours after reperfusion,which may be mainly induced by the increased production of oxygen radical species.The late phase results from inflammatory responses at 6 hours or more after reperfusion,leading to the progression of liver damage.The mechanism of IRIof the liver is a complex and muhifactorial process.The review outlines the current progress in the understanding of hepatic IRI from microcirculation,cellular,andmolecular levels,respectively.
