Expression and significance of VEGF-D and MMP-2 in pancreatic carcinoma
- VernacularTitle:胰腺癌组织中VEGF-D、MMP-2的表达及意义
- Author:
Shanzheng CHEN
;
Yixiong LI
;
Xuequn REN
;
Langqing JIANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Vascular endothelial growth factor D;
Gelatinase A
- From:
Journal of Chinese Physician
2008;10(3):291-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of VEGF-D and MMP-2 and explore their relationship with tumor invasion and local metastasis in pancreatic carcinoma.Methods The expression of VEGF-D and MMP-2 in 30 patients with pancreatic carcinomas and 6 cases with normal pancreatic tissues were detected by SABC immunohistochemical method.Results The positive rates of VEGF-D and MMP-2 proteins were 60%(18/30)and 66.7%(20/30)respectively,no expression of VEGF-D and MMP-2 was detected in normal pancreatie tissues.The expression of VEGF-D was significantly correlated with lymph node metastasis(P＜0.05),and the expression of MMP-2 was significantly correlated with lymph node metastasis and tumor local invasion(P＜0.05).The expression of VEGF-D protein Was positively correlated with MMP-2 protein(rs=0.54,P＜0.01).Conclusions There is a significantly positive correlation between high expression of VEGF-D and MMP-2 proteins in pancreatic carcinoma,and they may contribute to the invasive properties of pancreatic cancer.
