A modified thrombolytic scheme for the treatment of thrombosis in anatomically varied cerebral venous sinus
- VernacularTitle:改良溶栓方案治疗解剖变异的脑静脉窦血栓形成
- Author:
Lin ZHAO
;
Linfang LI
;
Zengpin LIU
;
Huimin QIN
;
Tiegang WANG
;
Gunhe ZHOU
- Publication Type:Journal Article
- Keywords:
venous sinus;
anatomical variation;
thrombolysis;
intervention;
urokinase;
microdose
- From:
Journal of Interventional Radiology
2010;19(3):174-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the curative effect of unremitting pump infusion of microdose urokinase(100 000 u/24 h)into the cerebral venous sinus in treating thrombosis in cerebral venous sinus which had anatomical variation. Methods Mechanical disruption of the thrombus and unremitting pump infusion of microdose urokinase(100 000 u/24 h)into the cerebral venous sinus for 48-96 hours were employed in 9 patients with thrombosis in anatomically varied cerebral venous sinus.After the procedure the original disorder was actively treated and the anticoagulant therapy was continued for 6 months.A follow-up of 6-12 months(mean 10 months) was conducted. Results Recanalization of the previously occluded cerebral venous sinus was obtained in all 9 patients.The dose of urokinase was 100 000 u/24 h in 8 patients.For the remaining one patient the dose of urokinase was 100 000 u/24 h in the first 48 hours,then the dose Was increased to 250 000u/24 h. Excellent result was obtained in all patients.Conclusion Unremitting pump infusion of microdose urokinase into the cerebral venous sinus can effectively treat the thrombosis in anatomically varied cerebral venous sinus.
