Serum CD147 and MMP-2 levels in patients with colorectal cancer and their significance
- VernacularTitle:大肠癌患者血清CD147和MMP-2水平的变化及意义
- Author:
Zhifan XIONG
;
Jie LI
;
Shiqiong CAO
;
Hao LIU
;
Zhihui LIU
;
Li LI
;
Zhenyin LI
;
Yanru WU
;
Lina XIONG
- Publication Type:Journal Article
- Keywords:
Intestinal neoplasms;
Gelatinase A;
Antigens,CD
- From:
Journal of Chinese Physician
2008;10(4):478-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of CD147 and MMP-2 and the relationship between these proteins and colorectal tumor differentiation, Dukes stage. Methods Serum levels of CD147 and MMP-2 in 44 patients with colorectal carcinoma,28 polyp intestinal patients and 36 normal subjects were measured by ELISA. Results Serum levels of CD147(103.59±40.74pg/ml)and MMP-2(14.92±2.02ng/ml)in the cancer patients were significantly higher than those of the polyp intestinal(66.27±16.91;10:96±1.71)and normal control(63.84±18.71;10.49±1.61)(P＜0.05).The levels were associated with tumor differentiation and Dukes stage. Patients with poor differentiation had significantly higher levels of MMP-2 than those of patients with well differentiation. And Dukes C and D stage tumors had significantly higher levels of CD147 than Dukes A and B stage tumors(P＜0.05).The levels of CD147 and MMP-2 declined remarkably after one month of radical operation. Conversely, it decreased illegibly after palliative operation. The serum levels of CD147were positively correlated with MMP-2 in patients with colorectal cancer. Conclusion Elevated CD147 and MMP-2 serum levels are associated with tumor differentiation, invasion, metastasis. Dynamic alterations of serum CD147 and MMP-2 may be used as the indicators of diagnosis, the choice of operative method and the judgment of prognosis in patients with colorectal cancer.
