Effect of xenon intervention on delayed neuropsychologic sequelae in acute carbon monoxide poisoning
- VernacularTitle:氙气防治一氧化碳中毒迟发性脑病的实验研究
- Author:
Shouzhi FU
;
Yong LIU
;
Jialiang WANG
;
Xiaoquan LI
;
Guodong PAN
- Publication Type:Journal Article
- Keywords:
Delayed neuropsyehologic sequelae;
Acute carbon monoxide poisoning;
Zenon;
Animal ethology;
Apoptosis
- From:
Chinese Journal of Emergency Medicine
2008;17(5):487-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of xenon intervention on delayed neuropsychologic sequelae (DNS)in acute carbon monoxide(CO)poisoning.Method Adult Wistar rats were randomly divided into sustained group,early intervention group,and control group.CO(150 ml/kg)was infused by intraperitoneal injection to produce DNS model.In sustained intervention group(S-group),xenon(150 ml/kg/d)was infilsed by intraperitoneal injection for 2 weeks;in control group(C-group),xenon was replaced by equal volume air;and in early intervention group(E-tvoup),xenon(150 ml/kg/d)was,employed in the first 3 days and air(150 ml/kg/d)was substituted for xenon in the following days until 2 weeks after CO poisoning.Morris maze test was used to evaluate the intelligence of rats.The long-term potentiation(LTP)of hippocampus Was detected by neuroelectricity recording.The apoptosis rates in brain was detected by TUNEL staining.The data were expressed as(x±s)and analyzed with student's test and analysis of variance.A P value less than 0.05 indicated statisfical significance.Results After exposure to CO,poisoned rats showed intelligence decline,demyeliation ofwater matler and cell apoptosis increased,which were consistent with DNS.In S-group and E-group,the rates of DNS and apoptosis were significantly lower than those in C-group,whereas the rote of LTP in S-group and E-group Was significantly higher than those in C-group.Conclusions Early xenon intervention can effectively decrease the rates of DNS occurred after acute CO poisoning.
